Minor Use Pesticide Program (MUPP) Residue Analysis - Pest Management Centre

1.2.1 This bid solicitation is being issued to satisfy the requirement of Agriculture and Agri-Food Canada. It is intended to result in the award of multiple contracts from contract award to March 31, 2025.
AAFC is requesting proposals for the conduct of chemical analysis for pesticide residues on crop samples collected from field trials at several Canadian locations, in accordance with the requirements of the Organization for Economic Co-operation and Development (OECD) Principles of Good Laboratory Practices (GLP) (rev 1997), study plans (Appendix A Annex 2), and Health Canada’s Pest Management Regulatory Agency “Residue Chemistry Guidelines” (PMRA Guidance Document, Updated Residue Chemistry Guidelines - Canada.ca)

For the purpose of preparing proposals, it is not a requirement to bid on all Projects. Proposals must be submitted on a Project number basis and not by study number. A Project consists of all the respective studies specific to a given Project number, the active ingredient, the commercial product and the crop(s) involved.

It is expected that AAFC may have to contract with several different companies to complete the identified laboratory analysis for the specified Projects. However, the degree of work that will be contracted is dependent upon many factors, including the response level to this RFP.

Only the analytical methods as in the list of projects in Annex 1 of this Appendix can be used.
The methods may be obtained as indicated below:

Project 1: AAFC23-004R (prohexadione calcium)
Method # 564/0: Validation of the analytical method 564/0: Method for the determination of Prohexadione-Ca in plant and animal matrices, BASF DocID 2005/1007581, A. Lehmann, C. Mackenroth, BASF Agricultural Center Limburgerhof, 23 March 2005.

Methods belonging to BASF Canada Inc., must be requested from
Carlan Downs-Cline, Tel: 919-525-7263; email: carlan.downs@basf.com

Project 2: AAFC21-009R (bentazon)
Method # S11-02666: Validation of an Analytical Method for the Determination of Bentazone and its Metabolites 6-OH-bentazone and 8-OH-bentazone in Plant Material, S11-02666, M. Tanguy, H. Weber, Eurofins Agroscience Services Chem GmbH, 10 Feb 2012.

Method belonging to UPL AgroSolutions Canada Inc., must be requested from
Namrata Gosar, Tel: 416-876-9252; email: namrata.gosar@upl-ltd.com

Project 3: AAFC23-011R (captan)
Method # S12-04646: Validation of an analytical method for the determination of Captan and its metabolite THPI in Crops, S12-04646, D. Schulz, Eurofins Agroscience Services Chem GmbH, 15 Dec 2015.

Methods belonging to Adama Agricultural Solutions Canada Ltd., must be requested from Bruno Jose Sanchez, Tel: 604-655-3057; email: bruno.sanchez@adama.com

Project 4: AAFC23-003R (clomazone)
Method # FMC-59299: Magnitude of the residue of Clomazone in representative Field Bean Raw Agricultural Commodities after One Application of COMMAND 48 EC in Northern Europe – 2022, FMC-59299, A. Prieur, SGS France Laboratoire de Rouen, 14 Feb 2023.

Method belonging to FMC of Canada Limited, must be requested from
Theresa Geil, Tel: 226-979-2247; email: theresa.geil@fmc.com

Project 5: AAFC23-017R (pyrethrins and PBO)
Method # GPL-MTH-074: Determination of Pyrethrins and Piperonyl Butoxide (PBO) in Crops, GPL-MTH-074, M. R. Huebner, S. Selim, Golden Pacific Laboratories, 24 May 2010.

Methods belonging to McLaughlin Gormley King Company, must be requested from
Beth Connor, Tel: 519-830-7837; email: beth.connor@valent.com

Project 6: AAFC23-008R (cyclaniliprole)
Method # JSM0269: IKI-3106 and NK-1375: Validation of Methodology for the Determination of Residues of IKI-3106 and NK-1375 in Grape, Wine, Peaches, Oilseed Rape Seeds and Dry Beans, JSM0269, S. Brewin, Huntingdon Life Sciences ltd., 04 Oct 2012.

Method belonging to ISK Biosciences Corporation, must be requested from
Karol Krey, Tel: 216-372-2569; email: kreyk@iskbc.com

Project 7: AAFC22-028R (azoxystrobin, propiconazole, pydiflumetofen)
1. Method # RAM 305/03: Residue Analytical Method for the Determination of Azoxystrobin (ICI5504) and R230310 in Crop Samples. Final Determination by LC-MS/MS, RAM 305/03, S. Chaggar, S.J. Crook, E.A. Harron, N.J. Robinson, 25 Nov 2004.
2. Method # AG-454B: Determination of Total Residues of Propiconazole in Crops as 2,4-Dichlorobenzoic Acid by Capillary Gas Chromatography, AG-454B, J. Toth, P.J. Manuli, 20 Dec 1989.
3. Method # GRM061.03A: SYN545974-Analytical Method for Determination of SYN545974 in Crops by LC-MS/MS with Validation Data, GRM061.03A, S-B. Huang, 24 Jun 2015.

Method belonging to Syngenta, which must be requested from CDN Syngenta Regulatory Contact (Tel: 519-836-5665); email: CDNSyngenta.RegContact@syngenta.com

Project 8: AAFC23-012R (cyprodinil, fludioxonyl)
1. Method # REM 141.10: Residue Method for The Determination of Residues of Cyprodinil (CGA 219417) in Crops. Final Determination by LC-MS/MS, REM 141.10, S. Chaggar, 09 May 2005.
2. Method # REM 133.06: Analytical Method for the Determination of Residues of Fludioxonil (CGA 173506) in Crop Matrices. Final Determination by LC-MS/MS, REM 133.06, C. H. Nichols, 30 Jun 2006.

Method belonging to Syngenta, which must be requested from CDN Syngenta Regulatory Contact (Tel: 519-836-5665); email: CDNSyngenta.RegContact@syngenta.com

Project 9: AAFC23-001R, AAFC23-002R (pyridate)
Method # S11-03700: Validation of an Analytical Method for the Determination of Pyridate, Pyridafol (CL 9673) and CL 9673-hydrolysable Conjugates in Plant Material, S11-03700, H. Weber, Eurofins Agroscience Services Chem GmbH, 24 Apr 2012.

Method belonging to BELCHIM Crop Protection Canada, must be requested from
Emily Falls, Tel: 226-332-0881; email: emily.falls@belchim.com

Frozen samples will be shipped to the successful bidder(s) (laboratory) upon harvest from ongoing field trials and/or from the AAFC Analytical Laboratory. Anticipated harvest dates are indicated on the List of Projects (Appendix A, Annex 1). The exact shipping dates will be determined after the contract is awarded. Storage stability data will be required if, at the time of analysis, samples have been stored longer than the storage stability timeframe indicated on the List of Projects.

With the exception of modifications necessary to adapt the methods to different crop fractions, AAFC expects the methods to be followed as written. This applies specifically to the equipment (detector) used to determine the residue definition. If, however, upon review of the method provided, the bidder believes that a different detector can be used, a rationale for the modification must be clearly indicated in the proposal and all impacts or changes in the procedures on the reference method indicated. Upon awarding contracts, all proposed modifications must be thoroughly discussed with the Study Director and approved prior to method validation.

For the purpose of preparing proposals, it is not a requirement to bid on all Projects. Proposals must be submitted on the basis of Project number and not by study number. A Project consists of all the respective studies specific to a given Project number, the active ingredient, the commercial product, the crop(s), the number of trials conducted and the number of samples per trial (treated and untreated). The list of Projects for which proposals are being sought is included in Appendix A, Annex 1. A study plan amendment template outlining analytical procedures to be followed is included in Appendix A, Annex 2. The Residue Analysis Application Form (Appendix C – Annex 1) must be completed for each Project for which a bid is being made.

As field trials are subject to the forces of nature throughout the growing season and possible changes in regulatory requirements, there is a possibility in either the cancellation of trials or changes in the number of samples required for residue analysis. This may result in the need to amend this RFP or to adjust contracts to reflect changes.

Bids must be in Canadian dollars. Evaluations for cost per point are calculated on the total cost of the individual Project, excluding HST. HST can only be collected if your company has a HST registration number. For further information please contact Canada Revenue Agency at:
http://www.ccra-adrc.gc.ca/sitemap-e.html#tax.

The failure to provide bids in Canadian dollars will make the proposal non-compliant. AAFC will reject any bid not in Canadian currency.

It is expected that AAFC will have to contract with several different companies to complete the identified laboratory analysis for the specified Projects. However, the degree of work that will be contracted is dependent upon many factors, including the response level to this RFP.