COMPUTATIONAL CHEMISTRY SIMULATIONS OF PHARMACEUTICAL BASED AGENTS

Trade Agreement: Canadian Free Trade Agreement (CFTA)
Tendering Procedures: The bidder must supply Canadian goods and/or services
Competitive Procurement Strategy: Best Overall  Proposal
Comprehensive Land Claim Agreement: No
Nature of Requirements: 



IMPORTANT: This tender is part of Public Works and Government Services Canada’s initiative to submit bid submission files electronically using epost Connect. Interested bidders should refer to Part 2 of the solicitation document entitled Instructions to bidders/offerors/suppliers, as the case may be, for instructions on how to participate and submit their files electronically for this tender.

** WE HAVE MOVED! Effective September 30, bids will be received at Canada Place, Suite 1000, 9700 Jasper Avenue, Edmonton AB, T5J 4C3**


1.  TITLE: COMPUTATIONAL CHEMISTRY SIMULATIONS OF PHARMACEUTICAL BASED AGENTS, DRUG DISCOVERY AND CHEMICAL ABSORPTION

2.  SECURITY:
There is no security requirement associated with the requirement.

3.  REQUIREMENT:
Defence Research and Development Canada (DRDC)-Suffield Research Centre requires information on the physical properties of some pharmaceutical based agents (PBAs) and medical countermeasures (MCMs) that they cannot determine experimentally. They also require information on how these molecules interact with various solutions and biological systems.  Current calculations in the literature do not account for enough of the physical environment surrounding the PBAs or MCMs to produce accurate representations of the interaction of these molecules in biological systems. DRDC-Suffield would like high-level quantum calculations to predict these interactions. For drug-repurposing DRDC-Suffield Research Centre also requires high-level calculations of hybrid quantum mechanics/molecular mechanics (QM/MM) to discover drugs against protein targets based on approved drugs by US Federal Drug Administration (FDA). For small molecule capture using Metal-Organic Frameworks (MOFs), the screening calculations are needed to determine the best candidates of MOFs for chemical absorption.


To qualify a bid will have to consist of no less than 80% of goods and/or services of Canadian origin. 


4. EVALUATION AND SELECTION:  
Mandatory and point rated technical evaluation criteria are included in Annex "D" of the solicitation. 

The responsive bid with the highest number of points will be recommended for award of a contract, provided that the total evaluated price does not exceed the budget available for this requirement.

5. OWNERSHIP OF INTELLECTUAL PROPERTY:
Any intellectual property arising from the performance of the Work under the Contract will vest in Canada. 

6. PERIOD OF CONTRACT: 
It is anticipated that any contract will be effective from date of Contact award to 2020-03-31 with three (3) option years and two (2) "GO-NO GO" optional tasks (Tasks 5.2.3 and 5.2.4).


Contracting Authority

Lorraine Jenkinson  
Procurement Specialist 
Public Works and Government Services Canada 
Procurement Branch, Western Region 
Canada Place, Suite 1000
9700 Jasper Avenue NW
Edmonton AB, T5J 4C3 

Telephone: 587-337-2458  
Facsimile: 780-497-3510 
E-mail address: lorraine.jenkinson@pwgsc-tpsgc.gc.ca

Delivery Date: Above-mentioned

The Crown retains the right to negotiate with suppliers on any procurement.

Documents may be submitted in either official language of Canada.