Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure

NOTICE OF PROPOSED PROCUREMENT (NPP)


Solicitation #:  1000174482         Closing Date:  September 2, 2015       Time:  2 p.m. EDT

This requirement is for the department of Health Canada.

Title: 
Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure

Scope:
The Inhalation Toxicology Laboratory (ITL) and Analytical Biochemistry and Proteomics Laboratory (ABPL) of Health Canada requires expert assistance with the bioinformatic analysis of high content proteomic mass spectral data derived from air pollution toxicology studies. 

Objectives of the Requirement
The objective of this requirement is to complete expert bioinformatic analyses of the data generated in an investigation of the in vitro toxicity of ambient particulate matter impacted by source emissions on lung epithelial and mouse macrophage cell lines.  The analyses will be used by Health Canada researchers to identify molecular changes relevant to air pollution toxicity in cell and animal models, and publish the results of the research in peer reviewed scientific publications.


Ownership of Intellectual Property:
The Crown will retain ownership of the copyright.


Security Requirement: 
The Contractor personnel requiring access to PROTECTED information, assets or sensitive work site(s) must EACH hold a valid RELIABILITY STATUS, granted or approved by Canadian Industrial Security Directorate (CISD) of PWGSC.  If the winning bidder does not hold this security screening level, the supplier will be required to obtain it before the contract is awarded.


Mandatory Requirements: 

M1.  The Bidder's proposed project leader must have a minimum of five (5) years experience by the date of this RFP working as a bioinformatician in a proteomics laboratory. 

M2.  The Bidder's proposed project leader must hold as a minimum an Master of Science (M.Sc.) in biology; and a graduate diploma or degree in bioinformatics. 

M3.   The Bidder must provide two references from previous work/projects conducted by the proposed project leader that are similar to the work outlined in this requirement’s Statement of Work. The references must be a former client’s Project Authority/Project Lead from a previous project.

M4.  The Bidder must provide a resource with at least 6 years of work experience from the date of this RFP in conducting bioinformatic analyses of proteomic data. 
		
		
Selection Methodology
The contract will be awarded based on a determination of best value taking into account both the technical merit of the proposals and the price evaluations.  To arrive at an overall score achieved by a firm, a weighting has been established whereby technical merit will be valued at 70% of the bid and price at 30%.


Enquiries regarding this Request for Proposals are to be submitted in writing to: 

Robert Merrick
Contracting Authority
E-mail:   Robert.Merrick@hc-sc.gc.ca