ADVANCED DEVELOPMENT OF BIOMARKERS OF SEPSIS, RALSTON, ALBERTA

Trade Agreement: Agreement on Internal Trade (AIT)
Tendering Procedures: All interested suppliers may submit a bid
Competitive Procurement Strategy: 
Comprehensive Land Claim Agreement: No
Nature of Requirements: 

1. TITLE:

ADVANCED DEVELOPMENT OF BIOMARKERS OF SEPSIS

2. REQUIREMENT:

Defence Research and Development Canada (DRDC) - Suffield Research Centre has an interest in DNA-based presymptomatic indicators of infection or sepsis. Biomarkers based on nucleic acids offer the potential to assess the stage and degree of disease processes. In sepsis, the presence of live microbes in the blood and the clinical syndrome due to them is a hallmark of potentially lethal infection with biological threat agentsand of pathogenic agents in general

A large prospective sepsis study of human cases of sepsis (and matched controls) is currently underway in the United Kingdom.  Comprehensive panels of serum have been accrued, matched to cases and outcomes.  DRDC Suffield has the opportunity to expand and add value to this by executing analysis of circulating nucleic acids (DNA) in existing study-derived serum samples, which collaborating partners have agreed to share for the purposes of developing novel biomarkers. The methods to perform DNA analysis exist already, and are being used to research many disease or injury processes. A large subset of existing samples will be screened by next-generation DNA sequencing, to identify biomarkers indicative of sepsis withstatistical support for association between biomarker and sepsis. Bioinformatics analysis will be used to identify and quantify biomarker DNA fragments, and to map biomarker evolution against time.  

3. PERIOD OF THE CONTRACT: 

The period of the contract is from date of contract for two (2) years.  

4. EVALUATION CRITERIA:

Mandatory technical criteria, point rated technical criteria, and management evaluation criteria are included in Annex “D”.

5. BASIS OF SELECTION:

Contractor selection will be based on the bidder that submits the highest technically acceptable proposal provided that the total evaluated bid price does not exceed the established budget.

6. OWNERSHIP OF INTELLECTUAL PROPERTY:

Crown owned

Delivery Date: Above-mentioned

The Crown retains the right to negotiate with suppliers on any procurement.

Documents may be submitted in either official language of Canada.