POINT-OF-CARE QUANTUM DOT DIAGNOSTIC DEVICE

Trade Agreement: Agreement on Internal Trade (AIT)
Tendering Procedures: All interested suppliers may submit a bid
Attachment: None
Competitive Procurement Strategy: Best Overall  Proposal
Comprehensive Land Claim Agreement: No
Nature of Requirements: 
TITLE

POINT-OF-CARE QUANTUM DOT DIAGNOSTIC DEVICE FOR THE MULTIPLEXED
IDENTIFICATION OF DISEASE PATHOGENS AND BIOLOGICAL THREAT AGENTS

REQUIREMENT

Defence Research and Development (R&D) Canada (DRDC), an agency
of the Department of National Defence (DND), has a requirement
to demonstrate and deliver a rapid hand-held point-of-care (PoC)
in vitro diagnostic device (IVDD) employing quantum dot (QD)
nanotechnology for the simultaneous (multiplexed) identification
of both endemic disease pathogens and biological threat agents
in a single sample.  This device must be usable as an
early-symptomatic treatment decision support tool by Canadian
Forces (CF) personnel on deployment.  

The project will demonstrate a QD hand-held, diagnostic tool,
capable of multiplexed analysis of samples, i.e., capable of
detecting multiple pathogens, including both endemic and
biological warfare (BW) threat agents, in a single clinical
sample of biological origin (e.g., blood). This QD technology
will enable the CF to rapidly identify viral, bacterial, and
parasitic agents leading to presumptive diagnoses, assisting
with determining treatment regimens and with epidemiological
analyses.  PoC diagnostics will provide a capability for
limiting the effects of a contagious illness and reducing, and
possibly eliminating, morbidity and mortality through earlier
use of prophylaxis and treatment. The QD diagnostic device to be
developed under this project will be beneficial in operational
scenarios involving:

Short notice deployment to regions harboring endemic disease
where little medical support is available;
Deployment to regions where there is a threat of, or actual, BW
agent use;
Repatriation of possibly infected deployed personnel; and
Assistance to the civil authority for biological public health
threats. 

The Contractor will be required to do the following:

Develop and demonstrate a proof-of-concept, QD, hand-held, PoC
device capable of the simultaneous identification of multiple
targets (Anthrax protective antigen, differentiate between past
and current exposure to dengue fever virus (serotypes 1-4), and
malaria (differentiating exposure to Plasmodium falciparum
versus exposure to other Plasmodium spp.)) in a blood sample.
Develop and demonstrate a prototype QD PoC diagnostic device
that meets all of the required physical and performance
specifications.
Design and conduct a complete laboratory trial and an end user
trial for the prototype QD PoC diagnostic device.
Complete all required documentation to seek Health Canada
Investigational Testing Approval for an in vitro diagnostic
device.

The period of the Contract is for 42 months from date of
Contract.

The requirement is subject to the provisions of the Agreement on
Internal Trade (AIT).

All interested suppliers may submit a bid.

EVALUATION PROCEDURES

Bids will be assessed in accordance with the entire requirement
of the bid solicitation including the mandatory and point rated
technical evaluation criteria.

MANDATORY TECHNICAL CRITERIA

At bid closing time, the Bidder must comply with the following
mandatory technical criteria and provide the necessary
documentation to support compliance. Any bid which fails to meet
the following mandatory technical criteria will be declared
non-responsive.  Each criterion should be addressed separately.  

Mandatory technical evaluation criteria are included in
Attachment 3 of the bid solicitation.

POINT RATED TECHNICAL EVALUATION CRITERIA

Point rated technical evaluation criteria are included in
Attachment 3 of the bid solicitation.

SELECTION METHOD

To be declared responsive, a bid must:

(a)	comply with all the requirements of the bid solicitation;

(b)	meet all mandatory technical evaluation criteria;

(c)	obtain the required minimum points overall for the technical
evaluation criteria which are subject to point rating.

Bids not meeting (a) or (b) or (c) will be declared
nonresponsive.

The responsive bid with the highest number of points will be
recommended for award of a contract, provided that the total
evaluated price does not exceed the budget available for this
requirement.  In the event that the highest number of points is
obtained by more than one responsive bid, the responsive bid
with the lowest evaluated price will be recommended for award of
a contract.

CONTRACTING AUTHORITY

Scott McRae
Supply Team Leader 

Public Works and Government Services Canada
Acquisitions Branch
Science Procurement Directorate 
Place du Portage III, 11C1 
11 Laurier Street
Gatineau, Québec  
K1A 0S5 

Phone: (819) 956-1383 
email:	scott.mcrae@tpsgc-pwgsc.gc.ca

All enquiries must be submitted in writing to the Contracting
Authority no later than ten (10) calendar days before the bid
closing date.
Delivery Date: Above-mentioned

The Crown retains the right to negotiate with suppliers on any
procurement.

Documents may be submitted in either official language of Canada.