Mass Spectrometer

Trade Agreement: WTO-AGP/NAFTA/AIT/Canada FTAs with
Peru/Colombia/Panama
Tendering Procedures: Generally only one firm has been invited
to bid
Attachment: None
Non-Competitive Procurement Strategy: Exclusive Rights
Comprehensive Land Claim Agreement: No
Vendor Name and Address: 
AB Sciex LP
71 Four Valley Dr
Concord Ontario
Canada
L4K4V8
Nature of Requirements: 
Marlene Hall
Supply Specialist
Telephone:  204 984-6423
E-mail:  marlene.hall@pwgsc-tpsgc.gc.ca

File No.: 6D063-132702/A



TITLE:	Mass Spectrometer

Public Works and Government Services Canada (PWGSC), on behalf
of Public Health Agency Canada (PHAC), Canadian Science Centre
for Human and Animal Health (CSCHAH), intends to negotiate with
AB Sciex LP for the provision of a QTRAP 6500 Mass Spectrometer.


DEFINITION OF REQUIREMENT

Public Health Agency Canada (PHAC) has a requirement for a QTRAP
6500 Mass Spectrometer for biological research. The Mass
Spectrometry and Proteomics (MSP) Core Facility supports
National Microbiology Laboratory (NML) in mass spsectrometry
analysis. The MSP provides NML with access to mass spectrometry
and proteomics instrumentation, software, methods, training,
information, and networking. MSP's key technologies include
2D-LV/MS/MS and MALDITOF MS, which are used to measure
biological systems at the protein level. These tools are used to
provide services and applications for better prevention,
treatment and diagnosis of infectious disease. The QTRAP 6500
and accompanying components will be for providing NML with new
diagnostic services,  e.g., target quantitiaiton for biomarker
verification, validation, and detection. These new services are
needed to help fulfill NML mandate for rapid, molecular-based
diagnostics of infectious disease and bioterrorism-telated
activity.


MINIMUM PERFORMANCE CRITERIA / SPECIFICATIONS

Any interested supplier must demonstrate by way of a statement
of capabilities that its product meets the following mandatory
requirements:

Due to space constraints, require a bench-top triple quadrupole
mass spectrometry system that has a footprint no larger than 32
inches by 32 inches (not including a nitrogen generator or
computer). The instrument's top panel must be able to support
the weight of typical HPLC and nanoLC devices, and the LC must
be of the appropriate size (same or smaller footprint and less
than 32-inches in height) and spill-proof design.
The MS and LC systems must be able to switch between nano-flow
(100-1000 nl/min) and micro-flow (1-50 ul/min) easily
(plug-and-play) and fast (within minutes). This is required to
enable switching between different applications for our various
clients at NML that require more sensitivity (nano-flow) or more
robustness (micro-flow).
As a core lab servicing many clients with many different types
of biological samples, we require simple plug-and-play nano-LC
chips/cartridges for rapid (< 1 min) changing of columns and
easy-of-use.  This is also required to enable out-sourcing of
the column costs to our clients. NanoLC column cartridges must
be separate from the electrospray tip to enable changing of the
tip independently of the column.  The columns must be housed in
a temperature controlled chamber for minimizing variability
within analytical separations. 
A 5-2000 m/z mass range for quadrupole scanning is required for
analysing target peptides of interest.
MRM-triggered full scan MS/MS carried out simultaneously for
peptides detected by MRM in a cycle time less than 5 ms which
required for structural validation of target peptides without
compromising quantitative (MRM) measurements. MS/MS collected
simultaneously, within the same run to the MRM experiment, must
have product ion sensitivities to detect and sequence 1-5 amol
of BSA peptides on a nanoLC column.
Must have the ability to carry out MRM3, an experiment for the
quantitation of peptides when background interferences in
complex matrices prevent the required LLOQ to be attained by MRM
alone.  Instrument must support this experiment by both hardware
and software and provide automated tuning for MRM3 methods for
peptides.   MRM3 experiments must be performed in a cycle time
less than 200 ms for analytical reproducibility for nanoLC
separations of peptides in biological proteolytic digests.
Ion detector capable of up to 6 orders or more of linear dynamic
range required for spanning the concentration range of target
peptides of interest.


JUSTIFICATION FOR PRE-IDENTIFIED SUPPLIER

AB Sciex LP is the only known supplier that can provide a Mass
Spectrometer that meets all of the mandatory performance
specifications.


TRADE AGREEMENTS

The following limited tendering reasons pertain to this
requirement:

Government Contract Regulations, Part 1, Section 6(d) only one
person is capable of performing the contract.

Government on Internal Trade (AIT), Article 506-12(b) where
there is an absence of competition for technical reasons and the
goods or services can be supplied only by a particular supplier
and no alternative or substitute exists;

North American Free Trade Agreement (NAFTA), 1016.2(b) where,
for works of art, or for reasons connected with the protection
of patents, copyrights or other exclusive rights, or proprietary
information or where there is an absence of competition for
technical reasons, the goods or services can be supplied only by
a particular supplier and no reasonable alternative or
substitute exists;

World Trade Organization Agreement on Government Procurement
(WTO-AGP), Article XV(b) when, for works of art or for reasons
connected with protection of exclusive rights, such as patents
or copyrights, or in the absence of competition for technical
reasons, the products or services can be supplied only by a
particular supplier and no reasonable alternative or substitute
exists;


DELIVERY DATE

The equipment must be delivered on or before March 31, 2014, FOB
destination.


PRE-IDENTIFIED SUPPLIER

AB Sciex LP
71 Four Valley Drive
Concord, On
L4K 4V8
Delivery Date: Above-mentioned

You are hereby notified that the government intends to negotiate
with one firm only as identified above. Should you have any
questions concerning this requirement, contact the contracting
officer identified above.

An Advance Contract Award Notice (ACAN) allows departments and
agencies to post a notice, for no less than fifteen (15)
calendar days, indicating to the supplier community that it
intends to award a good, service or construction contract to a
pre-identified contractor. If no other supplier submits, on or
before the closing date, a Statement of Capabilities that meets
the requirements set out in the ACAN, the contracting authority
may then proceed with the award.  However, should a Statement of
Capabilities be found to meet the requirements set out in the
ACAN, then the contracting authority will proceed to a full
tendering process.

Suppliers who consider themselves fully qualified and available
to provide the services/goods described herein, may submit a
statement of capabilities in writing to the contact person
identified in this Notice on or before the closing date of this
Notice. The statement of capabilities must clearly demonstrate
how the supplier meets the advertised requirements.

The PWGSC file number, the contracting officer's name and the
closing date of the ACAN must appear on the outside of the
envelope in block letters or, in the case of a facsimile
transmission, on the covering page.

The Crown retains the right to negotiate with suppliers on any
procurement.

Documents may be submitted in either official language of Canada.