Q-Exactive System

Trade Agreement: WTO-AGP/NAFTA/AIT/Canada FTAs with
Peru/Colombia/Panama
Tendering Procedures: Generally only one firm has been invited
to bid
Attachment: None
Non-Competitive Procurement Strategy: Exclusive Rights
Comprehensive Land Claim Agreement: No
Vendor Name and Address: 
THERMO FISHER SCIENTIFIC (MISSISSAUGA) INC.
2845 Argentia Rd
Unit 4
Mississauga Ontario
Canada
L5N8G6
Nature of Requirements: 
Marlene Hall
Supply Specialist
Telephone:  204 984-6423
E-mail:  marlene.hall@pwgsc-tpsgc.gc.ca
File No.: 6D063-132294/A



TITLE:	Q-Exactive System

Public Works and Government Services Canada (PWGSC), on behalf
of Public Health Agency Canada (PHAC), intends to negotiate with
Thermo Fisher Scientific Mississauga Inc. for the provision of a
Q-Exactive System.

DEFINITION OF REQUIREMENT
Public Health Agency Canada (PHAC) has a requirement for a
LC/MS/MS System for biological research. The Mass Spectrometry
and Proteomics (MSP) Core Facility supports National
Microbiology Laboratory (NML) in mass spectrometry analysis. Our
key technologies include 2D-LC/MS/MS and MALDI-TOF MS, which are
used to measures biological systems at the protein level. We use
these tools to provide services and applications for better
prevention, treatment and diagnosis of infectious disease. The
Q-Exactive and accompanying components must function as an
interchangeable unit in a suite of two other pre-existing
Orbitrap-based instruments, LTQ Orbitrap XL and LTQ Orbitrap
Velos. This is necessary in order that the lab can generate
comparable data sets for current projects with large sample
numbers requiring multiple instruments. It is imperative that
the new system is compatible with pre-existing platforms to
scale-up and increase sample-throughput capacity. 

In order to maintain consistency in our research and downstream
analysis, having access to the same technology is imperative. To
analyze historical data and to be able to compare it to new data
generated, we need to use the same make of instrument. The
inability to statistically compare old data to new data would
have adverse outcomes for our scientific data and potential for
publications.  

MINIMUM PERFORMANCE CRITERIA / SPECIFICATIONS
Any interested supplier must demonstrate by way of a statement
of capabilities that its product meets the following mandatory
requirements:
	a bench top nano-LC/MS/MS system that spans no more than 95 cm
in width due to space constraints;
	Resolution of at least 100,000 FWHM and mass accuracy < 1 (3)
ppm with internal (external) calibration. High resolution is
required for the deconvolution of overlapping ion signals, e.g.,
near-isobaric peptides or fragments, in the analysis of complex
matrices, and improving highest possible confidence in protein
identification;

	As a core lab servicing many clients with many different types
of biological samples, we require simple plug-and-play nano-LC
columns for rapid (< 1 min) changing of columns and easy-of-use;

	Different peptide fragmentation options for peptide sequencing
and PTM analysis: Collision Induced Dissociation (CID) and
Higher Energy Collisional Dissociation (HCD);

	In addition to biomarker discovery workflows, must have rapid
targeted quantitation/biomarker screening with multiplexed SIM
and multiplexed MS/MS spectra of up to 10 simultaneously
detected precursor ions;

	The nano-LC/MS/MS must be able to function as an
interchangeable unit in a suite of two other pre-existing
Orbitrap-based instruments. This is necessary in order that the
lab can generate comparable data sets for current projects with
large sample numbers requiring multiple instruments.

JUSTIFICATION FOR PRE-IDENTIFIED SUPPLIER
Thermo Fisher Scientific is the only known supplier that can
provide a bench-top nano-LC/MS/MS that meets all of the
mandatory performance specifications and will integrate with
existing data-processing pipelines already in lab use, including
Proteome Discoverer, Mascot, and Scaffold for iTRAQ and TMT
experiments.

SECURITY REQUIREMENT
There is a security requirement associated with this requirement.

TRADE AGREEMENTS
The following limited tendering reasons pertain to this
requirement:

Government Contract Regulations, Part 1, Section 6(d) only one
person is capable of performing the contract.

Government on Internal Trade (AIT), Article 506-12(a) to ensure
compatibility with existing products, to recognize exclusive
rights, such as exclusive licences, copyright and patent rights,
or to maintain specialized products that must be maintained by
the manufacturer or its representative;

North American Free Trade Agreement (NAFTA), 1016.2(d) for
additional deliveries by the original supplier that are intended
either as replacement parts or continuing services for existing
supplies, services or installations, or as the extension of
existing supplies, services or installations, where a change of
supplier would compel the entity to procure equipment or
services not meeting requirements of interchangeability with
already existing equipment or services, including software to
the extent that the initial procurement of the software was
covered by this Chapter;

World Trade Organization Agreement on Government Procurement
(WTO-AGP), Article XV(d) for additional deliveries by the
original supplier which are intended either as parts replacement
for existing supplies, or installations, or as the extension of
existing supplies, services or installation where a change of
supplier would compel the entity to procure equipment or
services not meeting requirements of interchangeability with
already existing equipment or services;

DELIVERY DATE
The equipment must be delivered on or before March 31, 2014, FOB
destination.

PRE-IDENTIFIED SUPPLIER
Thermo Fisher Scientific Mississauga Inc.
2845 Argentia Road, Unit 4
Mississauga, Ontario
L5N 8G6  Canada




	
Delivery Date: Above-mentioned

You are hereby notified that the government intends to negotiate
with one firm only as identified above. Should you have any
questions concerning this requirement, contact the contracting
officer identified above.

An Advance Contract Award Notice (ACAN) allows departments and
agencies to post a notice, for no less than fifteen (15)
calendar days, indicating to the supplier community that it
intends to award a good, service or construction contract to a
pre-identified contractor. If no other supplier submits, on or
before the closing date, a Statement of Capabilities that meets
the requirements set out in the ACAN, the contracting authority
may then proceed with the award.  However, should a Statement of
Capabilities be found to meet the requirements set out in the
ACAN, then the contracting authority will proceed to a full
tendering process.

Suppliers who consider themselves fully qualified and available
to provide the services/goods described herein, may submit a
statement of capabilities in writing to the contact person
identified in this Notice on or before the closing date of this
Notice. The statement of capabilities must clearly demonstrate
how the supplier meets the advertised requirements.

The PWGSC file number, the contracting officer's name and the
closing date of the ACAN must appear on the outside of the
envelope in block letters or, in the case of a facsimile
transmission, on the covering page.

The Crown retains the right to negotiate with suppliers on any
procurement.

Documents may be submitted in either official language of Canada.